BGB-A445
Product Specifications
CAS Number
3033874-57-3
Target
NF-κB, OX Receptor
Related Pathways
NF-κB, Neuroscience, GPCR/G Protein
Bioactivity
BGB-A445 is a humanized non-ligand blocking agonistic OX40 monoclonal antibody with high affinity for OX40. It activates the downstream NF-κB pathway, inducing activation, proliferation, and survival of immune cells. BGB-A445 significantly depletes regulatory T cells in a dose-dependent manner via antibody-dependent cellular cytotoxicity (ADCC) . In the MC38 mouse model, BGB-A445 demonstrates potent, dose-dependent antitumor efficacy and is applicable in cancer studies, such as colorectal adenocarcinoma.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
CAU35846-01 100 µL
Anti-Fc Fragment Of IgG Low Affinity IIIa Receptor (FcgR3A) Monoclonal Antibody
Sign In for Pricing
View Details CAU35846-02 200 µL
Anti-Fc Fragment Of IgG Low Affinity IIIa Receptor (FcgR3A) Monoclonal Antibody
Sign In for Pricing
View Details CAU35846-03 1 mL
Anti-Fc Fragment Of IgG Low Affinity IIIa Receptor (FcgR3A) Monoclonal Antibody
Sign In for Pricing
View Details 
VAng-Lsx05383-50gEcoli 50 µg (E. coli)
Recombinant Candida Albicans CCP2 Protein (aa 1-291)
Sign In for Pricing
View Details