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ART5803

Product Specifications

CAS Number

3058434-76-4

Target

IGluR

Related Pathways

Neuroscience, Membrane transporter/Ion channel

Bioactivity

ART5803 is a humanized IgG1 monoclonal antibody inhibitor targeting NMDAR. It binds with high affinity to the N-terminal domain (NTD) of the NMDAR GluN1 subunit (GluN1-NTD) . ART5803 blocks the internalization of NMDAR induced by pathogenic autoantibodies and restores the expression and function of NMDAR on the cell surface. Moreover, ART5803 reverses behavioral abnormalities and the expression of NMDAR in marmoset disease models. ABT-147 can be utilized in research on anti-NMDAR encephalitis.

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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