ART5803
Product Specifications
CAS Number
3058434-76-4
Target
IGluR
Related Pathways
Neuroscience|||Membrane transporter/Ion channel
Bioactivity
ART5803 is a humanized IgG1 monoclonal antibody inhibitor targeting NMDAR. It binds with high affinity to the N-terminal domain (NTD) of the NMDAR GluN1 subunit (GluN1-NTD) . ART5803 blocks the internalization of NMDAR induced by pathogenic autoantibodies and restores the expression and function of NMDAR on the cell surface. Moreover, ART5803 reverses behavioral abnormalities and the expression of NMDAR in marmoset disease models. ABT-147 can be utilized in research on anti-NMDAR encephalitis.
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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