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UB-221

Product Specifications

CAS Number

2755114-30-6

Target

Others

Related Pathways

Others

Bioactivity

UB-221 is a humanized IgG1 monoclonal antibody inhibitor that targets IgE. It significantly reduces IgE synthesis by stabilizing the membrane-bound CD23 on B lymphocytes and inhibits FcԑRI-mediated activation and degranulation of basophils. UB-221 lowers IgE levels in cynomolgus monkeys and human IgE (ε, κ) transgenic (hIGHE knock-in) mice, making it relevant for asthma and chronic spontaneous urticaria (CSU) research.

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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