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RO5323441

Product Specifications

Target

VEGFR

Related Pathways

Tyrosine Kinase/Adaptors, Angiogenesis

Bioactivity

RO5323441 (TB-403) is a human IgG1 monoclonal antibody (mAb) that specifically targets PLGF. It inhibits the binding of human PlGF-1 or PlGF-2 to VEGFR-1, with IC50 values of 0.1 and 0.2 nM, respectively. RO5323441 effectively blocks PlGF-induced phosphorylation of VEGFR-1 in Flt-1 transfected HEK293 cells and exhibits antitumor activity.

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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