VTX-0811
Product Specifications
Target
TNF|||NF-?B|||c-Myc
Related Pathways
Apoptosis|||Cell Cycle/Checkpoint|||NF-?B
Bioactivity
VTX-0811 is a human IgG4 monoclonal antibody (mAb) that targets PSGL1/CD162. It modulates immune signaling pathways by enhancing TNF-?/NF-?B and chemokine-mediated signaling while reducing oxidative phosphorylation, fatty acid metabolism, and Myc signaling. VTX-0811 increases the proportion of CD8+ T cells among infiltrating T cells and exhibits antitumor activity in humanized mouse PDX models of melanoma.
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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