PLX-4545
Product Specifications
CAS Number
2892065-45-9
Target
Ligand for E3 Ligase|||Molecular Glues
Related Pathways
PROTAC
Bioactivity
PLX-4545 has oral biological activity and is a cereblon based IKZF2 (zinc finger transcription factor Helios) molecular gel degrading agent that acts on immune suppressive regulatory T cells, reprogramming them into pro-inflammatory effector T cells and enhancing anti-tumor immune response.
Smiles
O([C@@H]1[C@H](CCCC1)N2CC(C2)C3=CC=CC=C3)C=4C=C5C(=CC4)C(=O)N(C5)[C@@H]6C(=O)NC(=O)CC6
Molecular Formula
C28H31N3O4
Molecular Weight
473.56
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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