FiVe1
Product Specifications
CAS Number
932359-76-7
Target
Others, Proteasome
Related Pathways
Ubiquitination, Proteases/Proteasome, Others
Purity
0.9968
Bioactivity
FiVe1 is a vimentin binding small molecule that promotes the disintegration and phosphorylation of vimentin in the metaphase, leading to mitotic disasters, polynuclearization, and loss of cancer cell dryness. FiVe1 selectively and irreversibly inhibit the growth of mesenchymal transformed breast cancer cells (FOXC2-HMLER cell, IC50=234nM) and soft tissue sarcomas of different histological subtypes.
Smiles
ClC=1C2=C(C(=CN=N2)N3CCN(CC3)C4=CC(Cl)=CC=C4)C=CC1
Molecular Formula
C18H16Cl2N4
Molecular Weight
359.25
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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