SR12343
Product Specifications
CAS Number
2055101-86-3
Target
IκB/IKK, NF-κB
Related Pathways
NF-κB
Purity
0.9991
Bioactivity
SR12343 is a small molecule inhibitor of the IKK/NF-κB signaling pathway that functions as a NEMO-binding domain (NBD) mimetic. SR12343 inhibits NF-κB activation with an IC50 of 37.02 μM by specifically blocking the critical IKKβ-NEMO interaction, reduces pulmonary inflammation in models, and is suitable for research into inflammatory and degenerative diseases.
Smiles
O=C(NCCC=1C=CC=C(Br)C1)CNC2=NC=C(Cl)C=C2
Molecular Formula
C15H15BrClN3O
Molecular Weight
368.66
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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