KU004
Product Specifications
CAS Number
1260401-93-1
Target
Apoptosis, Akt, EGFR, ERK
Related Pathways
MAPK, Angiogenesis, JAK/STAT signaling, Apoptosis, PI3K/Akt/mTOR signaling, Cytoskeletal Signaling, Tyrosine Kinase/Adaptors
Bioactivity
KU004, a potent dual EGFR/HER2 inhibitor, exhibits anticancer properties. It inhibits the proliferation of human breast cancer SKBR3 cells by inducing G1 phase arrest. KU004 blocks the activation of HER2, EGFR, and the downstream Akt and Erk pathways, primarily inducing apoptosis (Apoptosis) through the extrinsic pathway. Additionally, KU004 is a novel quinazoline derivative.
Smiles
O=P1(C)CCN(CC#CC=2C=CC3=NC=NC(NC4=CC=C(OCC=5C=CC=C(F)C5)C(Cl)=C4)=C3C2)CC1
Molecular Formula
C29H27ClFN4O2P
Molecular Weight
548.98
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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