Evo312
Product Specifications
CAS Number
2820245-53-0
Target
PKC, Apoptosis
Related Pathways
Chromatin/Epigenetic, Apoptosis, Cytoskeletal Signaling
Bioactivity
Evo312 is an inhibitor of protein kinase C beta I (PKCβI) with an IC50 of 117.34 nM and exhibits dose-dependent characteristics. It acts by inhibiting the expression of the PKCβI protein, which leads to cell cycle arrest and apoptosis in PANC-GR (gemcitabine-resistant pancreatic cancer cells) . Evo312 also demonstrates antiproliferative effects in pancreatic cancer cells PANC-1 and PANC-GR, with IC50 values of 0.08 μM and 0.07 μM respectively, while presenting an IC50 of 2.95 μM in normal human pancreatic ductal epithelial cells HPDE6-c7. Additionally, Evo312 has shown antitumor activity in a mouse xenograft model using PANC-GR cells.
Smiles
O=C(OC=1C=CC=2NC3=C(C2C1)CCN4C(=O)C=5C=CC=CC5N(C)C34)C
Molecular Formula
C21H19N3O3
Molecular Weight
361.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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