VEGFR-2-IN-52
Product Specifications
CAS Number
3046428-94-5
Target
Apoptosis|||Reactive Oxygen Species|||VEGFR
Related Pathways
NF-?B|||Apoptosis|||Metabolism|||Angiogenesis|||Tyrosine Kinase/Adaptors|||Immunology/Inflammation
Bioactivity
VEGFR-2-IN-52 (compound 14d) serves as a powerful inhibitor of VEGFR-2, exhibiting an IC 50 of 191.1 nM. It effectively reduces the protein expression levels of p-VEGFR-2, MMP9, p-ERK1/2, and p-MEK1. In addition, VEGFR-2-IN-52 demonstrates cytotoxic properties by inducing apoptosis and arresting the cell cycle at the G0/G1 phase, and it enhances the levels of ROS.
Smiles
O=C(N)C1=C(SC=C1C=2C=CC(Cl)=CC2)NC(=O)NCCCCN3CCCC3
Molecular Formula
C20H25ClN4O2S
Molecular Weight
420.96
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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