PROTAC SMARCA2/4-degrader-26

PROTAC SMARCA2/4-degrader-26 is a PROTAC targeting the SMARCA2/4 proteins. It is composed of the ligand for PROTAC targeting proteins, 2- (4- (3-Amino-6- (2-hydroxyphenyl) pyridazin-4-yl) piperazin-1-yl) acetic acid, an E3 ligase component (2S,4R) -4-Hydroxy-N- (4- (4-methylthiazol-5-yl) benzyl) pyrrolidine-2-carboxamide, and a PROTAC linker (S) -2-Amino-3,3-dimethylbutanoic acid. The coupled complex of the E3 ubiquitin ligase ligand + Linker is referred to as (S, R, S) -AHPC.