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PROTAC SMARCA2/4-degrader-31

Product Specifications

CAS Number

2568273-83-4

Target

Epigenetic Reader Domain|||PROTACs

Related Pathways

Chromatin/Epigenetic|||PROTAC

Bioactivity

PROTAC SMARCA2/4-degrader-31 (Compound I-280) serves as a degrader for the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. It effectively degrades SMARCA2 in A549 cells and SMARCA4 in MV411 cells, both with a degradation concentration (DC50) of less than 100 nM.

Smiles

O=C1N(C=2C(=CC(=CC2)[C@@H]3CC[C@H](CC3)N4CCC(CC4)C=5N=C(C=CN5)N6C7CN(CC6CC7)C=8C=C(N=NC8N)C9=C(O)C=CC=C9)N1C)C%10C(=O)NC(=O)CC%10

Molecular Formula

C44H51N11O4

Molecular Weight

797.95

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Product Datasheet

https://www.targetmol.com/attachment/DataSheet/240554098108137483/T89934

Available Sizes

Curated Selection

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