Neptinib
Product Specifications
CAS Number
2085843-51-0
Target
EGFR
Related Pathways
JAK/STAT signaling, Tyrosine Kinase/Adaptors, Angiogenesis
Bioactivity
Neptinib (NEP010), a derivative of Afatinib, exhibits enhanced antitumor properties and improved pharmacokinetics when administered orally. It demonstrates a notable suppression of tumor expansion in mouse models of non-small cell lung cancer harboring various EGFR mutations. Furthermore, Neptinib effectively inhibits the EGFR kinase family, exhibiting IC 50 values of 0.24 nM for EGFR wt, 7.25 nM for EGFR L858R/T790M, 0.46 nM for EGFR L858R, and 1.79 nM for EGFR T790M.
Smiles
N(C=1C2=C(C=C(OCC)C(NC(/C=C/CN(C)C)=O)=C2)N=CN1)C3=CC(Cl)=C(F)C=C3
Molecular Formula
C22H23ClFN5O2
Molecular Weight
443.9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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