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AURKA against 1

Product Specifications

Target

Aurora Kinase

Related Pathways

Cell Cycle/Checkpoint, Chromatin/Epigenetic

Bioactivity

Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.

Molecular Formula

C28H32FN9O2

Molecular Weight

545.61

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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