SMART1
Product Specifications
Target
Akt, PROTACs, Ras, PDK, Kras
Related Pathways
Cytoskeletal Signaling, MAPK, PROTAC, PI3K/Akt/mTOR signaling
Bioactivity
SMART1 is a CRBN-dependent PROTAC with high specificity that effectively degrades Smurf1. It inhibits tumor growth in xenograft models of colorectal cancer (CRC) with KRAS mutations and blocks the PDK1-Akt signaling pathway in KRAS-mutated colorectal cancer.
Molecular Formula
C40H35N9O7
Molecular Weight
753.76
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
