SMART1
Product Specifications
Target
Akt|||PROTACs|||Ras|||PDK|||Kras
Related Pathways
Cytoskeletal Signaling|||MAPK|||PROTAC|||PI3K/Akt/mTOR signaling
Bioactivity
SMART1 is a CRBN-dependent PROTAC with high specificity that effectively degrades Smurf1. It inhibits tumor growth in xenograft models of colorectal cancer (CRC) with KRAS mutations and blocks the PDK1-Akt signaling pathway in KRAS-mutated colorectal cancer.
Molecular Formula
C40H35N9O7
Molecular Weight
753.76
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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