SMART1
Product Specifications
Target
Akt|||PROTACs|||Ras|||PDK|||Kras
Related Pathways
Cytoskeletal Signaling|||MAPK|||PROTAC|||PI3K/Akt/mTOR signaling
Bioactivity
SMART1 is a CRBN-dependent PROTAC with high specificity that effectively degrades Smurf1. It inhibits tumor growth in xenograft models of colorectal cancer (CRC) with KRAS mutations and blocks the PDK1-Akt signaling pathway in KRAS-mutated colorectal cancer.
Molecular Formula
C40H35N9O7
Molecular Weight
753.76
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
RR203825L4V 200 µL
LOC316124 (NM_001134566) Rat Tagged ORF Clone Lentiviral Particle
Ask
View Details 
130103-ML550 100 µL
MYST3 (Histone Acetyltransferase KAT6A, MOZ, YBF2/SAS3, SAS2 and TIP60 Protein 3, MYST-3, Monocytic Leukemia Zinc Finger Protein, Runt-related Transcription Factor-binding Protein 2, Zinc Finger Protein 220, KAT6A, MOZ, RUNXBP2, ZNF220, MGC167033) (MaxLight 550)
Ask
View Details