Camptothecin-d5
Product Specifications
CAS Number
1329616-37-6
Target
ADC Cytotoxin
Related Pathways
Antibody-drug Conjugate/ADC Related
Bioactivity
Camptothecin-d5 is a deuterated derivative of Camptothecin (CPT), an alkaloid and an inhibitor of DNA topoisomerase I (Topo I) with an IC50 value of 679 nM. Camptothecin (CPT) exhibits potent antitumor activity against colorectal, breast, lung, and ovarian cancers by modulating the expression pattern of miRNA and regulating the activity of hypoxia-inducible factor-1α (HIF-1α) in human cancer cells.
Smiles
[C@](C([2H])([2H])[2H])([C@]1(O)C2=C(C(=O)N3C(=C2)C=4C(C3)=CC=5C(N4)=CC=CC5)COC1=O)([2H])[2H]
Molecular Formula
C20H16N2O4
Molecular Weight
353.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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