D3S-001
Product Specifications
CAS Number
2914919-85-8
Target
Ras, Kras
Related Pathways
MAPK
Bioactivity
D3S-001 is an orally effective KRAS inhibitor. It suppresses the proliferation of the KRASG12C mutants H358 and MIA-PA-CA-2 with IC50 values of 0.6 and 0.44 nM, respectively. D3S-001 exhibits good metabolic stability across multiple species in hepatocytes, liver microsomes, plasma, and whole blood. Additionally, it demonstrates favorable pharmacokinetic properties and antitumor activity in mice.
Smiles
C(OC1=NC(=C2C(=N1)C[C@H](OC2)C3=C(C(F)(F)F)C(C)=CC(N)=C3F)N4C[C@H](CC#N)N(C(C(=C)F)=O)CC4)[C@@]56N(C[C@H](F)C5)CCC6
Molecular Formula
C32H35F6N7O3
Molecular Weight
679.66
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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