PROTAC SMARCA2/4-degrader-15

PROTAC SMARCA2/4-degrader-15 (Compound I-335) is a PROTAC degrader designed for the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. It degrades SMARCA2 in A549 cells with a DC50 of less than 100 nM; similarly, it degrades SMARCA4 in MV411 cells, also with a DC50 of less than 100 nM.

NC1=C(N2CC3N(C(C2)CC3)C=4N=CC(=CN4)C5=CC=C(CC(N[C@H](C(=O)N6[C@H](C(NCC7=CC=C(C=C7)C8=C(C)N=CS8)=O)C[C@@H](O)C6)C(C)(C)C)=O)C=C5)C=C(N=N1)C9=C(O)C=CC=C9