Anticancer agent 249

Anticanceragent 249 (Compound 89) is an inhibitor of Hsp90β, exhibiting an IC50 of 16.5 μM in PC3MM2 cells. It suppresses the proliferation of various cancer cell lines including MCF-7, T47D, MDA-MB-231, MDA-MB-468, and SKBr3, with IC50 values ranging from 1.8 to 5.3 μM. Additionally, Anticanceragent 249 induces apoptosis in MDA-MB-231 cells and demonstrates antitumor activity in mice.