What is the catalog number for XM-U-14?

The catalog number for XM-U-14 is T89347.

What sizes are available for XM-U-14?

XM-U-14 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does XM-U-14 come in?

XM-U-14 is available in 2 different pack sizes.

XM-U-14 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures XM-U-14?

XM-U-14 is manufactured by Molfinity.

What is the estimated delivery time for XM-U-14?

Estimated delivery time for XM-U-14 is approximately 10 business day(s), depending on your location.

XM-U-14

Product Specifications

Target

DUB, Apoptosis, PROTACs, MDM-2/p53

Related Pathways

DNA Damage/DNA Repair, PROTAC, Apoptosis, Cell Cycle/Checkpoint, Ubiquitination

Bioactivity

XM-U-14 is a selective PROTAC USP7 degrader that induces the degradation of USP7 in the RS4;11 cell line with a DC50 of 0.74 nM. This compound elevates the levels of p53 and p21, and significantly inhibits the growth of acute lymphoblastic leukemia (ALL) cells, with IC50 values of 0.5 nM in RS4;11 cells and 8.3 nM in Reh cells. Moreover, XM-U-14 induces apoptosis and cell cycle arrest, and effectively inhibits tumor growth.