NLRP3-IN-34
Product Specifications
CAS Number
1392502-55-4
Bioactivity
NLRP3-IN-34 (Compound T10) acts as an inhibitor of the NLRP3 inflammasome. It blocks the production of reactive oxygen species (ROS) and impedes the formation of NLRP3 inflammasome-dependent IL-1? (J774A.1, IC50 of 0.48 ?M), while also inhibiting pyroptosis (cell suicide) . Additionally, NLRP3-IN-34 displays anti-inflammatory activity in a C57BL/6 mouse model for DSS-induced peritonitis.
Smiles
O=C(OC1C=2C=3C(=O)C(=O)C4=C(OC=C4C)C3C=CC2C(C)(C)CC1)C=5C=CC=CC5O
Molecular Formula
C26H22O6
Molecular Weight
430.45
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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