PROTAC SMARCA2 degrader-7
Product Specifications
CAS Number
2568277-71-2
Bioactivity
PROTACSMARCA2 degrader-7 (Compound I-428) is a PROTAC degrader targeting the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. In MV411, it achieves degradation of SMARCA2 and SMARCA4 with DC50 values of <100 nM and 100-500 nM, respectively.
Smiles
C(C12CCC(C(N[C@H](C(=O)N3[C@H](C(NCC4=CC=C(C=C4)C5=C(C)N=CS5)=O)C[C@@H](O)C3)C(C)(C)C)=O)(CC1)CC2)N6CCC(CC6)N7C=C(C=N7)C=8C=C(N=NC8N)C9=C(O)C=CC=C9
Molecular Formula
C50H62N10O5S
Molecular Weight
915.16
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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