TX-2552
Product Specifications
CAS Number
2446767-14-0
Bioactivity
TX-2552 is an orally effective inhibitor of tyrosyl-DNA phosphodiesterase 1 (TDP1), with an IC50 value of 0.62 μM. It enhances the cleavage activity of topotecan in mouse bone marrow cells and amplifies the antitumor effects of topotecan in Krebs-2 ascites tumor-bearing mice.
Smiles
O=C1C=C(C=2C(=CC(OC/C=C(/CCC=C(C)C)\C)=CC2)O1)C3=CC=C(F)C=C3
Molecular Formula
C25H25FO3
Molecular Weight
392.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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043643-ML550 100 µL
UQCRFS1, CT (UQCRFS1, Cytochrome b-c1 complex subunit Rieske, mitochondrial, Complex III subunit 5, Cytochrome b-c1 complex subunit 5, Rieske iron-sulfur protein, Ubiquinol-cytochrome c reductase iron-sulfur subunit, Cytochrome b-c1 complex subunit 11, Complex III subunit IX, Ubiquinol-cytochrome c reductase 8kD protein) (MaxLight 550) discontinued
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