ZG-2291
Product Specifications
CAS Number
2962103-40-6
Bioactivity
ZG-2291 is a selective inhibitor targeting FIH (hypoxia-inducible factor inhibitor) with oral activity. It selectively inhibits FIH by binding to it and inducing a conformational flip in a catalytically crucial tyrosine, without affecting other 2OG oxidases of the JmjC subfamily. ZG-2291 promotes thermogenesis and ameliorates obesity symptoms and metabolic dysfunctions in ob/ob mice. This compound holds promise for research in the field of obesity-related diseases.
Smiles
O=C(O)CNC(=O)C=1N=CC(=CC1O)C=2ON=C(C2)C=3C=CC=C(Cl)C3
Molecular Formula
C17H12ClN3O5
Molecular Weight
373.75
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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