Hsp110/sGC-modulator-1

Hsp110/sGC-modulator-1 (compound 17i) is a dual-target modulator of Hsp110 and sGC with oral activity, exhibiting optimal molecular activity against both Hsp110 and sGC targets. Additionally, it demonstrates significant inhibitory effects on malignant cellular phenotypes and vasodilation. Hsp110/sGC-modulator-1 (compound 17i) alleviates pulmonary vascular remodeling and right ventricular hypertrophy by inhibiting Hsp110.