PROTAC SMARCA2/4-degrader-9
Product Specifications
CAS Number
2568507-15-1
Bioactivity
PROTAC SMARCA2/4-degrader-9 (Compound I-503) is a PROTAC degrader targeting the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. It effectively degrades SMARCA2 in MV411 and A549 cells, with a DC50 of less than 100 nM, and degrades SMARCA4 in MV411 with a similar DC50.
Smiles
NC1=C(N2CC3N(C(C2)CC3)C=4N=CC(=CN4)C5CCC(C(N[C@H](C(=O)N6[C@H](C(NCC7=CC=C(C=C7)C8=C(C)N=CS8)=O)C[C@@H](O)C6)C(C)(C)C)=O)CC5)C=C(N=N1)C9=C(O)C=CC=C9
Molecular Formula
C49H59N11O5S
Molecular Weight
914.13
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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