OX-201
Product Specifications
CAS Number
2460722-03-4
Bioactivity
OX-201 is a selective agonist for OX2R with an EC50 of 8 nM. Pathological proteins produced by neurons are released into the interstitial fluid (ISF) in a neural activity-dependent manner and subsequently cleared from the brain via lymphatic pathways. The efflux of these proteins to the ISF correlates with the wakeful state of neurons. OX-201 can induce neuronal awakening and enhance the release of tau into the hippocampal ISF. While it does not alter hippocampal tau levels, OX-201 has potential applications in Alzheimers disease (AD) related to sleep/wake cycle disturbances.
Smiles
C([C@@H]1N(C(C(C)(C)O)=O)CC(F)(F)[C@@H]1NS(C)(=O)=O)C2=C(F)C(=CC=C2)C3=CC(F)=CC(F)=C3
Molecular Formula
C22H23F5N2O4S
Molecular Weight
506.49
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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