Brimarafenib
Product Specifications
CAS Number
1643326-82-2
Target
Raf
Related Pathways
MAPK
Purity
0.9832
Bioactivity
Brimarafenib is a selective RAF dimerization inhibitor, which can inhibit the activity of BRAF and CRAF, and exhibits significant inhibitory effects on a variety of RAF mutations (including BRAF I/II/III mutations, BRAF fusion and CRAF heterodimerization), and is used for the treatment of colorectal and pancreatic cancers and other solid tumors with MAPK mutations.
Smiles
N(C(NC1=C(F)C=C(F)C(F)=C1)=O)[C@H]2[C@]3([C@@]2(OC=4C3=CC(OC5=C6C(NC=C5)=NC(=O)CC6)=CC4)[H])[H]
Molecular Formula
C24H17F3N4O4
Molecular Weight
482.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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