What is the catalog number for SMARCA2-IN-8?

The catalog number for SMARCA2-IN-8 is T89051.

What sizes are available for SMARCA2-IN-8?

SMARCA2-IN-8 is available in the following size(s): 25 mg, 50 mg, 100 mg.

How many pack sizes does SMARCA2-IN-8 come in?

SMARCA2-IN-8 is available in 3 different pack sizes.

Is SMARCA2-IN-8 in stock?

SMARCA2-IN-8 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures SMARCA2-IN-8?

SMARCA2-IN-8 is manufactured by Molfinity.

What is the estimated delivery time for SMARCA2-IN-8?

Estimated delivery time for SMARCA2-IN-8 is approximately 10 business day(s), depending on your location.

SMARCA2-IN-8

Product Specifications

CAS Number

2270875-93-7

Bioactivity

SMARCA2-IN-8 (Compound 13) is an orally effective inhibitor targeting the SWI/SNF chromatin remodeling complexes SMARCA2 (also known as Brahma homolog, BRM) and SMARCA4 (also known as Brahma-related gene 1, BRG1), with IC50 values of 5 nM and 6 nM respectively. This compound inhibits the proliferation of SMARCA2-mutant SKMEL5 cancer cells with an AAC50 of 5 nM and downregulates the expression of the SMARCA2-dependent gene KRT80, showing an AAC50 of 10 nM. Additionally, SMARCA2-IN-8 demonstrates antitumor efficacy and favorable pharmacokinetic properties in mice.