KRAS inhibitor-25

Product Specifications

CAS Number

3030577-05-7

Target

Kras|||Ras

Related Pathways

MAPK

Bioactivity

KRAS inhibitor-25 (compound 151a), a pyrido[2,3-d]pyrimidine derivative, effectively inhibits KRas G12V, KRas WT, and KRas G12R with IC50 values all below 100 nM.

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C(OC1=NC2=C3C(=N1)C(F)=C(N=C3)C=4C(=C(Cl)C=C(O)C4)CCCCCCC5(O)CN2CCC5)[C@@]67N(C[C@H](F)C6)CCC7

Molecular Formula

C32H38ClF2N5O3

Molecular Weight

614.13

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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