RPS6-IN-1
Product Specifications
Target
Bcl-2 Family|||Caspase|||PARP|||Apoptosis|||Autophagy|||MDM-2/p53
Related Pathways
DNA Damage/DNA Repair|||Proteases/Proteasome|||Autophagy|||Apoptosis|||Chromatin/Epigenetic
Bioactivity
RPS6-IN-1 (Compound 22o) inhibits cell migration and induces apoptosis (increasing the expression of Bax, p53, cleaved-caspase 3, and cleaved-PARP) . It reduces mitochondrial membrane potential and activates autophagy (Autophagy) through the PI3K-Akt-mTOR signaling pathway, damaging mitochondria and lysosomes within the cell and causing endoplasmic reticulum stress. RPS6-IN-1 also inhibits the phosphorylation of RPS6. Notably, RPS6-IN-1 is a low systemic toxicity anticancer agent.
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Product Datasheet
https://www.targetmol.com/attachment/DataSheet/235843774842929162/T88975
Available Sizes
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