LMP7/LMP2-IN-1
Product Specifications
CAS Number
3053755-09-9
Target
Proteasome
Related Pathways
Proteases/Proteasome, Ubiquitination
Bioactivity
LMP7/LMP2-IN-1 (Compound 19) is an orally effective inhibitor targeting the immunoproteasome subunits LMP7 and LMP2, with respective IC50 values of 257 and 10 nM. This compound reduces the production of antibodies and downregulates the B cells in the germinal centers of the spleen and plasma cells in NP-OVA immunized mice. It has potential applications in the study of autoimmune diseases.
Smiles
C(N[C@H](B(O)O)C1CCCCC1)(=O)C2=CN(N=N2)C3CCCCC3
Molecular Formula
C16H27BN4O3
Molecular Weight
334.22
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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