AF3485
Product Specifications
CAS Number
1195786-61-8
Bioactivity
AF3485, a human mPGES-1 inhibitor, exhibits anti-tumor activity both in vitro and in vivo. It achieves this by reducing PGE2 production, inhibiting EGFR signaling, and decreasing the expression of VEGF and FGF-2, which suppresses tumor-associated angiogenesis. When subchronically administered to mice with human A431 xenograft tumors, AF3485 effectively curtails tumor growth.
Smiles
O=C(NC1=CC=C2C(=C1)C=3C=CC=CC3N2CCO)C=4C=CC=CC4C(F)(F)F
Molecular Formula
C22H17F3N2O2
Molecular Weight
398.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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