AF3485
Product Specifications
CAS Number
1195786-61-8
Bioactivity
AF3485, a human mPGES-1 inhibitor, exhibits anti-tumor activity both in vitro and in vivo. It achieves this by reducing PGE2 production, inhibiting EGFR signaling, and decreasing the expression of VEGF and FGF-2, which suppresses tumor-associated angiogenesis. When subchronically administered to mice with human A431 xenograft tumors, AF3485 effectively curtails tumor growth.
Smiles
O=C(NC1=CC=C2C(=C1)C=3C=CC=CC3N2CCO)C=4C=CC=CC4C(F)(F)F
Molecular Formula
C22H17F3N2O2
Molecular Weight
398.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
![p53 Tumor Suppressor Protein Recombinant Mouse Monoclonal Antibody [Clone rTP53/6927]](https://cdn.genprice.uk/genprice/uk/genprice5.webp)
MBS4382276-01 0.02 mg (With BSA & Azide at 0.2mg/mL)
p53 Tumor Suppressor Protein Recombinant Mouse Monoclonal Antibody [Clone rTP53/6927]
Sign In for Pricing
View Details MBS4382276-02 0.1 mg (With BSA & Azide at 0.2mg/mL)
p53 Tumor Suppressor Protein Recombinant Mouse Monoclonal Antibody [Clone rTP53/6927]
Sign In for Pricing
View Details MBS4382276-03 0.1 mg (Without BSA & Azide at 1mg/mL)
p53 Tumor Suppressor Protein Recombinant Mouse Monoclonal Antibody [Clone rTP53/6927]
Sign In for Pricing
View Details MBS4382276-04 5x 0.1 mg (With BSA & Azide at 0.2mg/mL)
p53 Tumor Suppressor Protein Recombinant Mouse Monoclonal Antibody [Clone rTP53/6927]
Sign In for Pricing
View Details MBS4382276-05 5x 0.1 mg (Without BSA & Azide at 1mg/mL)
p53 Tumor Suppressor Protein Recombinant Mouse Monoclonal Antibody [Clone rTP53/6927]
Sign In for Pricing
View Details