JMV7048
Product Specifications
Target
PROTACs
Related Pathways
PROTAC
Bioactivity
JMV7048 is an effective PROTAC degrader targeting the PXR (Pregnane X Receptor), with a DC50 of 379 nM. It induces the polyubiquitination and degradation of PXR protein by recruiting the E3 CRBN ubiquitin ligase and the 26S proteasome. This degradation of PXR significantly enhances the chemosensitivity of colorectal cancer stem cells, substantially delaying cancer recurrence in vivo. The composition of JMV7048 includes the PXR agonist JMV6944, a linker, and Thalidomide 5-fluoride.
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Product Datasheet
https://www.targetmol.com/attachment/DataSheet/235843774838734854/T88908
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
TXB-00241-01 100 mg
4-Methylumbelliferyl ?-D-N, N', N'', N'''-tetraacetylchitotetraoside
Ask
View Details 
TXB-00241-02 250 mg
4-Methylumbelliferyl ?-D-N, N', N'', N'''-tetraacetylchitotetraoside
Ask
View Details TXB-00241-03 50 mg
4-Methylumbelliferyl ?-D-N, N', N'', N'''-tetraacetylchitotetraoside
Ask
View Details 
MBS1093158-01 0.5 mg (E-Coli)
Recombinant Escherichia coli O17:K52:H18 Cell division protein FtsB (ftsB), partial
Ask
View Details