What is the catalog number for JMV7048?

The catalog number for JMV7048 is T88908.

What sizes are available for JMV7048?

JMV7048 is available in the following size(s): 10 mg, 50 mg.

How many pack sizes does JMV7048 come in?

JMV7048 is available in 2 different pack sizes.

JMV7048 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures JMV7048?

JMV7048 is manufactured by Molfinity.

What is the estimated delivery time for JMV7048?

Estimated delivery time for JMV7048 is approximately 10 business day(s), depending on your location.

JMV7048

Product Specifications

Target

PROTACs

Related Pathways

PROTAC

Bioactivity

JMV7048 is an effective PROTAC degrader targeting the PXR (Pregnane X Receptor), with a DC50 of 379 nM. It induces the polyubiquitination and degradation of PXR protein by recruiting the E3 CRBN ubiquitin ligase and the 26S proteasome. This degradation of PXR significantly enhances the chemosensitivity of colorectal cancer stem cells, substantially delaying cancer recurrence in vivo. The composition of JMV7048 includes the PXR agonist JMV6944, a linker, and Thalidomide 5-fluoride.