PROTAC SMARCA2/4-degrader-4
Product Specifications
CAS Number
2568523-81-7
Bioactivity
PROTAC SMARCA2/4-degrader-4 (Compound I-434) is a PROTAC degrader targeting the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. It efficiently degrades SMARCA2 in MV411 and A549 cell lines with a DC50 of less than 100 nM and degrades SMARCA4 in MV411 cells, also with a DC50 of less than 100 nM.
Smiles
O=C(NCC=1C=CC(=CC1)C=2SC=NC2C)C3N(C(=O)C(NC(=O)C4CC5(C4)CC(C6=CC=C(C=C6)CN7CCC(CN8N=CC(=C8)C=9C=C(N=NC9N)C=%10C=CC=CC%10O)CC7)C5)C(C)(C)C)CC(O)C3
Molecular Formula
C56H66N10O5S
Molecular Weight
991.25
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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