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TYRA-300

Product Specifications

CAS Number

2800223-30-5

Target

FGFR

Related Pathways

Tyrosine Kinase/Adaptors|||Angiogenesis

Purity

0.9966

Bioactivity

TYRA-300 is an oral and selective FGFR3 inhibitor with an IC50 value of 11 nM and 25-fold, 14-fold, and 36-fold selectivity for FGFR1, FGFR2, and FGFR4, respectively, in the Ba/F3 cell line for the treatment of metastatic uroepithelial carcinomas (mUCs) and chondrodysplasia.

Smiles

S(C)(=O)(=O)N1CC2(CN(C2)C3=CC=C(C=N3)C=4C=5C(NN4)=CC=C(O[C@H](C)C=6C(Cl)=CN=CC6Cl)C5)C1

Molecular Formula

C25H24Cl2N6O3S

Molecular Weight

559.47

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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