TAS2940 fumarate
Product Specifications
CAS Number
2758034-98-7
Target
EGFR
Related Pathways
Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors
Bioactivity
TAS2940 fumarate is a brain-penetrating, orally active, irreversible, and selective pan-ERBB inhibitor. It exhibits IC50 values of 5.6 nM, 2.1 nM, and 1.0 nM against wild-type HER2, HER2 V777L, and A775_G776insYVMA, respectively. TAS2940 fumarate is utilized for researching tumors characterized by abnormalities in HER2 and EGFR.
Smiles
C(=C/C(O)=O)\C(O)=O.C(#CC1CC1)C=2N(C=3C(C2C(N[C@H](C)C4=CC=CC=C4)=O)=C(N)N=CN3)[C@H]5CN(C(C=C)=O)[C@@H](C)C5
Molecular Formula
C32H34N6O6
Molecular Weight
598.65
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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