FLT3/CDKs ligand-1
Product Specifications
CAS Number
2452019-67-7
Target
FLT|||Ligands for Target Protein for PROTAC|||CDK
Related Pathways
PROTAC|||Cell Cycle/Checkpoint|||Angiogenesis|||Tyrosine Kinase/Adaptors
Bioactivity
FLT3/CDKs ligand-1 (Compound 14) functions as a ligand for target proteins, promoting the degradation of Cyclin-Dependent Kinases (CDK) and FMS-like tyrosine kinase 3 (FLT3), thereby inhibiting the proliferation and survival of leukemia cells associated with FLT3/CDK. This compound is also used in the synthesis of PROTAC FLT3/CDKs Degrader-1.
Smiles
O=C(OC(C)(C)C)N1CCN(CC2=CC=C(C=C2)NC(=O)C3=NNC=C3NC=4N=CN=C5NC=CC54)CC1
Molecular Formula
C26H31N9O3
Molecular Weight
517.58
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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