PHTPP-1304
Product Specifications
CAS Number
2410081-60-4
Target
Estrogen Receptor/ERR, Autophagy, AUTACs
Related Pathways
Endocrinology/Hormones, PROTAC, Autophagy
Bioactivity
PHTPP-1304, a chimeric autophagy-targeting compound (AUTOTAC) based on PHTPP, induces p62 self-oligomerization and degrades estrogen receptor ERβ (DC50: ~2 nM, HEK293T) . Additionally, PHTPP-1304 facilitates the formation of p62+ERβ+ puncta in a dose-dependent manner, influencing autophagic flux.
Smiles
C(F)(F)(F)C=1N2C(=C(C(=N2)C3=CC=CC=C3)C4=CC=C(OCCOCCOCCNC[C@H](COC5=CC(OCCCC6=CC=CC=C6)=C(OCC7=CC=CC=C7)C=C5)O)C=C4)N=C(C(F)(F)F)C1
Molecular Formula
C51H50F6N4O7
Molecular Weight
944.96
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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