Sp-8-Cl-cAMPS
Product Specifications
CAS Number
142754-28-7
Target
Others|||PKA
Related Pathways
Others|||Tyrosine Kinase/Adaptors
Bioactivity
Sp-8-Cl-cAMPS, as a derivative and analogue of cAMP, can inhibit the growth of various human tumor cells, such as leukemia cells HL-60 and colon cancer cells LS-174T, with an IC50 range of 8-100 ?M. In addition, this compound can activate protein kinase cAKI and cAKII, with Ka values of 0.25 ?M and 3.2 ?M, respectively.
Smiles
ClC=1N(C=2C(N1)=C(N)N=CN2)[C@H]3[C@H](O)[C@]4([C@](O3)(COP(=O)(S)O4)[H])[H]
Molecular Formula
C10H11ClN5O5PS
Molecular Weight
379.72
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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