UR778Br
Product Specifications
CAS Number
866127-80-2
Target
Apoptosis
Related Pathways
Apoptosis
Bioactivity
UR778Br targets the GTPase-activating protein-related domain (GRD domain) of the IQGAP1 protein. This compound inhibits the proliferation of human acute myeloid leukemia (AML) by arresting the cell cycle during the G2/M phase and inducing apoptosis (cell death) . UR778Br suppresses colony formation in primary cells and AML cells without significant effects on normal bone marrow cells.
Smiles
O=C(C=1C=CC=CC1O)CC2(O)C(=O)N(C3=CC=C(Br)C=C32)CCCC
Molecular Formula
C20H20BrNO4
Molecular Weight
418.28
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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