W4022
Product Specifications
CAS Number
2761292-51-5
Target
Histone Methyltransferase
Related Pathways
Chromatin/Epigenetic
Bioactivity
W4022 (compound 16) is an efficient dual inhibitor of the lysine methyltransferases G9a/NSD2, with IC50 values of 0.241 μM for G9a and 0.017 μM for NSD2. It exhibits potent antiproliferative properties, including the ability to suppress colony formation, induce apoptosis, and inhibit metastasis of cancer cells. W4022 effectively curtails the catalytic activities of G9a and NSD2 within cells and demonstrates significant antitumor efficacy in PANC-1 xenograft models.
Smiles
N#CC=1N=C2C=C(OCCCN3CCCC3)C(OC)=CC2=C(N1)NC4CCN(CC4)C(C)C
Molecular Formula
C25H36N6O2
Molecular Weight
452.59
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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