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Nampt-IN-12

Product Specifications

CAS Number

2427862-70-0

Target

NAMPT, Others

Related Pathways

Others, Metabolism

Bioactivity

Nampt-IN-12 (compound 9), a derivative of N-Pyridinylthiophene carboxamid, exhibits activity against peripheral nerve sheath cancer cells. It is metabolized by the enzymes NAMPT and NMNAT1 within the NAD salvage pathway into an adenine dinucleotide (AD) derivative, an analog of NAD that can inhibit inosine monophosphate dehydrogenase (IMPDH), leading to the accumulation of inosine monophosphate (IMP) within the cells. Nampt-IN-12's effective blood-brain barrier permeability makes it suitable for research into cancers of the central and peripheral nervous system.

Smiles

O=C(NC=1SC=CC1)C=2C=NC=CC2

Molecular Formula

C10H8N2OS

Molecular Weight

204.25

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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