PROTAC CDK4/6 degrader 1
Product Specifications
CAS Number
3025082-14-5
Target
Apoptosis, PROTACs, CDK
Related Pathways
Apoptosis, Cell Cycle/Checkpoint, PROTAC
Bioactivity
PROTAC CDK4/6 degrader 1 (Compound 7f) is a dual degrader of CDK4 and CDK6, with DC50 values of 10.5 nM and 2.5 nM, respectively. This compound effectively inhibits proliferation in Jurkat cells (IC50 of 0.18 μM), induces cell cycle arrest during the G1 phase, and triggers cell apoptosis (apoptosis) .
Smiles
O=C1C=NC=2C=NC(=NC2N1C3CCCC3)NC4=CC=C(C=C4)N5CCN(CC5)CCCCC(=O)NCCNC6=CC=CC=7C(=O)N(C(=O)C67)C8C(=O)NC(=O)CC8
Molecular Formula
C41H47N11O6
Molecular Weight
789.88
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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