Glucocorticoid receptor modulator 4

Product Specifications

CAS Number

2688785-30-8

Target

Glucocorticoid Receptor|||Drug-Linker Conjugates for ADC

Related Pathways

Endocrinology/Hormones|||Antibody-drug Conjugate/ADC Related

Bioactivity

Compound DL5, also known as Glucocorticoid receptor modulator 4, acts as a conjugate of linkers and glucocorticoid receptor regulators. It demonstrates GRE reporter activity in K562 cells expressing mTNF with an EC50 of 40 ?M. Additionally, Compound DL5 binds to anti-tumor necrosis factor (TNF) antibodies and exhibits anti-inflammatory properties in combating arthritis in mouse models.

Smiles

O(C(=O)C1=CC(NC([C@@H](NC([C@@H](NC(CBr)=O)C)=O)C)=O)=C(F)C=C1)[C@@]2(C(SCF)=O)[C@]3(C)[C@@](C[C@H]2C)([C@]4([C@](F)([C@@H](O)C3)[C@]5(C)C(CC4)=CC(=O)C=C5)[H])[H]